QUANTITATIVE STRUCTURE - ACTIVITY RELATIONSHIP STUDIES OF SOME BENZIMIDAZOLE ANALOGUES BASING ON PARTIAL LEAST SQUARES METHOD

Quantitative structure-activity relationship studies on benzimidazole derivatives as angiotensin II receptor were performed to explore the structural requirements for biologic activity. QSAR model obtained was statistically significant with r2 value of 0.8847, cross validated correlation coefficient q2 value of 0.7538 and pred_r2 value of 0. 8135, coefficient of correlation of predicted data set (pred_r2se) 0.5487 was developed by stepwise PLSR method. The observed activity of these molecules was consistent with the model, suggesting that the model may be useful in the design of potent antihypertensive agents.