Lipid Peroxidation and Antioxidant System in Men with Urogenital Lesions after Stomach Resection

Introduction. For the treatment of complicated peptic ulcer (PU) of gastroduodenal zone (GDZ) gastrectomy (GE) is still preferred, but in 78.3% of operated post-gastrorectomy disease (PGD) occurs, which can be in a form of 17 syndromes-urogenital, immunological, hormonal-metabolic, pancreatic-hepato-biliary, cardiovascular, etc. Due to the demographic crisis in Ukraine, caused by a decrease in fertility, and given the fact that GE is more often conducted to men of reproductive age, the impact of the operation on the state of the genitourinary system (GUS) requires more in-depth study, and the active interest in this problem is fully justified. In isolated cases, there is information that the activation of lipid peroxidation (LP) and weakening of the antioxidant system (AOS) play an important role in the pathogenesis of GUS lesions, but these processes in patients with GUS lesions after GE due to PU of GDZ have not been studied until now. Aim. To characterize the state of LP and the activity of the AOS in men with lesions of GUS after GE due to the ulcer of the gastroduodenal zone (GDZ). Materials and methods. In a randomized manner, 330 men, that 5 years or more had GE due to the complicated PU of GDZ were selected. The stomach resection according to the classic Balroth-I method was performed for 116 patients, according to Bilroth-II in the modification of the Gofmeister-Finsterer-214. In 67 patients, 1/2 of the stomach was cut, in 232 - 2/3 of the stomach, in 31 - 3/4 of the stomach. For all 330 patients clinical, laboratory tests (complete blood count and urinalisys, Zimnitskiy urine test, Nechyporenko urine test, urine sterility and sensitivity to antibiotics test, Reberga – Tareyev test, levels of creatinine and urea, basal concentration of testosterone in blood serum and instrumental examination (ultrasonographic examination of the urinary system, chest x-ray, radionuclide renography, scintigraphy, excretory urography, cavernosometry,cavrnosography, biostesiometry) were made. To verify the diagnosis the consulting of urologist and sexologist have been received. The treatment was carried out in the therapeutic department of Lviv Regional Clinical Hospital during 28-30 days. Results. It was found, that in late terms after GE due to the PU of GDZ in men with erectile dysfunction and chronic pyelonephritis there is a significant disturbance of LP and antioxidant protection. In most cases, these changes are manifested by the increase of LP, activation of enzymatic antioxidant and decrease of the membrane antioxidant. Conclusions. In our opinion these scientific results will help in the pathogenetic conservative treatment of patients with urogenital lesions after the GE with the application of antioxidants and unsaturated fatty acids.