Quantitative and Qualitative Estimation of Three Marketed Tablet Preparations of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone Commonly Used in Bangladesh

This study was aimed to evaluate the pharmaceutical quality of ranitidine hydrochloride, tiemonium methylsulfate and domperidone tablets manufactured in Bangladesh. Ten samples of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone solid dosage forms available in Bangladesh drug market were assayed spectrophotometrically and their various physical parameters such as weight variation, friability, disintegration, dissolution and hardness were analyzed according to British Pharmacopoeia (BP) and United States Pharmacopoeia (USP). Among them seven ranitidine, seven timonium and seven domperidone samples were meet the BP specification (95 – 105% of claimed potency). Study revealed that eight ranitidine, ten tiemonium and seven domperidone formulations of different companies meet the USP specification for in vitro dissolution test in first 30 minutes.