Comparison of Dehydroepiandrosterone Sulfate to Free Testosterone and Luteinizing Hormone to Follicular Stimulating Hormone Ratios in Polycystic Ovarian Syndrome Women

Objective: To compare Dehydroepiandrosterone Sulfate to Free Testosterone (DHEAS/FT) and Luteinizing Hormone to Follicular Stimulating Hormone (LH/FSH) ratios in Polycystic Ovarian Syndrome (PCOS) women. Material and Methods: The present study was done in the Department of Biochemistry in collaboration with Department of Obstetrics and Gynaecology in which 30 PCOS cases and 30 ages matched healthy controls were enrolled. Fasting venous blood samples were collected from cases and controls for routine biochemical and hormone analysis after obtaining written consent & complete history. Results: We found that free testosterone of cases (10.3 ± 17.1 pg/dL) showed significantly higher values than controls (1.84 ± 1.4 pg/dL) with p = 0.011 and had significantly positive correlation with Body Mass Index (BMI) with p = 0.014. DHEAS and FSH of cases had no significant raised value than controls (p > 0.05). LH of cases (12.7 ± 8.9 mIU/mL) had significantly higher than controls (7.02 ± 6.2 mIU/mL) with p = 0.006. DHEAS/FT of cases (0.815 ± 0.95) showed significantly lower than controls (1.922 ± 1.53) with p = 0.001. LH/FSH ratio (2.25 ± 2.3) of cases was significantly higher than controls (1.01 ± 0.72) with p = 0.008. LH/FSH ratio had 30% sensitivity and 93% specificity, but DHEAS/FT ratio had 16.7% sensitivity and 100% specificity for PCOS. Conclusion: In conclusion, DHEAS/FT ratio can be considered as a specific marker than LH/FSH ratio and LH/FSH ratio as a better sensitive marker than DHEAS/FT ratio in PCOS women.