The Influence of Targeting Central Venous Pressure (CVP) on Early Graft Function after Living Donor Kidney Transplantation

Introduction: Early graft function is very important and can be achieved with an adequate intraopeartive perfusion characteristics of the graft and urine output. The goal of this study was to examine the influence of targeting CVP on early graft function. Material and methods: After approval of Ethical committee of the Medical Faculty-Skopje we obtained inform consent of 60 patients ASA 2 - 3 undergoing renal transplantation of living-related person in the Clinic of Urology-Skopje. A prospective clinical study which was performed in the period of 2 years. They were divided in 2 groups of thirty patients: group A receiving normal saline intraoperativly targeting for CVP 15 mmHg until vascular clamps were off and group B receiving normal saline 10 ml/kg/h. We recorded onset of diuresis and total urine output from unclamping the renal vessels to the end of the surgery in both groups and postoperative serum, urine creatinin and FENa % in 3 times (3,12,36 hours). Results: The onset of diuresis in seconds was insignificantly longer in group B p > 0.05 (p = 0.31) we didn't find any statistical differences in postoperative serum creatinin in both groups. Conclusion: Our study didn't show any benefit from targeting CVP to 15 mmHg. We couldn't find any significant differences on onset of diuresis and urine output after the unclamping the vessels.