STUDY OF USING KOJIC ACID AS ANTICANCER IN DIFFERENT CONCENTRATION TO TREATMENT CANCERED RATS Rattus norvegicus BY CYCLOPHOSPHAMIDE

Objective: This study was conduct to investigate effect of kojic acid to treatment of cancered rate. Methods: Different concentration 0.5, 1, 2 mg/kg used as treatment through 30 days in some histological and functional criteria in cancered rats Rattus norvegicus by cyclophosphamide and the parameters that studied were WBC, PCV, HB , platelets , AST, ALT, and Bilirubin . Results: The result showed there is significant difference in blood parameters (WBC , platelets) at P≤ 0.01 and there is no significant difference in (HB , PCV) when compared with control group in addition T3, T4 , TSH levels showed no significant difference in all group of rats that treated with kojic acid when compared with control group at P≥ 0.01 also showed significant difference in ALT, AST, Bilirubin when compared with control group at P≤ 0.01 that lead to increase of ALT, AST, Bilirubin related to increase with kojic acid and then we showed significant change in the liver and kidney tissues in concentration 2 mg/kg of kojic acid when compared with control group and finally. Conclusion: We can consider the kojic acid is very good substance may be useful as antibiotic or antioxidant in some researches because it is very safe on the body .