Efficacy of a New Preparation Regimen with Mosapride and Low Volume of Water Intake for Endoscopy Preparation in Post gastrectomy Patients

Aim: Food retention is a frequent problem in patients who have previously undergone subtotal gastrectomy, which often makes endoscopy unsuccessful. This study evaluated the efficacy and patient tolerance of a new preparation regimen for upper gastrointestinal (UGI) endoscopy in patients who have undergone subtotal gastrectomy. Methods: A total of 135 patients with gastric cancer who underwent subtotal gastrectomy were enrolled for the study. They were divided into 3 groups: group A (40 patients) was used with mosapride with low-volume water intake; group B (40 patients) was used with large-volume water intake; group C (55 patients) underwent prolonged fasting before UGI endoscopy. The degree of food residue in the remnant stomach was classified according to endoscopic scoring system by blinded examiners. The tolerance of the new endoscopy preparation was assessed via questionnaires. Results: The mean residual food scores were lower in group A than in group C (0.35 ± 0.58 vs. 0.87 ± 0.84, p = 0.002). The group with the highest value of negative food residue was group A (70.0%), followed by group B (65.0%), and finally group C (40.0%). Tolerance to the preparation was higher, although not significantly different, in group B compared to group A (80% vs. 60%, p = 0.149).