COMPARATIVE STUDY ON EFFICACY OF ACECLOFENAC AND ACECLOFENAC PLUS TIZANIDINE IN PATIENTS WITH LOW BACK PAIN AT NEPAL MEDICAL COLLEGE AND TEACHING HOSPITAL

Aim To compare the efficacy of Aceclofenac and fixed dose combination of Aceclofenac and Tizanidine in the treatment of low back pain. Methodology This hospital based randomized, comparative prospective study was conducted with 100 outpatients suffering from LBP who met inclusion and exclusion criteria. The patients were randomized into Group A receiving Aceclofenac (100 mg) and Group B receiving fixed dose combination of Aceclofenac (100mg) and Tizanidine (2mg). Visual analog scale (VAS) was used to measure the pain score on 3rd day and 7th day during treatment. Results: The baseline mean score for pain in Group A and Group B was 6.37±1.75 and 6.82±1.24 respectively. On 3rd day, the mean pain score of Group A and Group B was reduced to 2.30±1.39 and 1.86±1.01 and on 7th day, the mean pain score was reduced to 1.40±1.19 and 0.75 ±0.872 respectively. There was statistically significant reduction in mean pain score on group B compared to group A at the end of the treatment (P=0.002). Conclusion Both the drug regimen (Aceclofenac and Aceclofenac+Tizanidine) were found to be effective while, Aceclofenac+Tizanidine had higher efficacy compared to Aceclofenac only at the end of treatment