A study of changes in stomach wall at sites other than the ulcer in chronic duodenal ulcer patients

Background: A duodenal ulcer is usually caused by an infection with a germ (bacterium) called Helicobacter pylori (H. pylori). A 4- to 8-week course of acid-suppressing medication will allow the ulcer to heal. Aim: To study changes in stomach wall at sites other than the ulcer in chronic duodenal ulcer patients. Materials and methods: This study was conducted in 150 patients in the department of surgery in Government General Hospital/ Government Medical College, Medical College, Nizamabad, during the period of July 2014 to May 2016. Results: In the present study, out of 150 patients in this study, 90 were males and 60 were females. Age ranged from 23 to 82 years old. In endoscopy findings, chronic gastritis of antrum was found to be 138 (92%), gastric ulcer was detected in 7% cases i.e. in 11 patients. The pangastritis rate was 65% and the inflammation was caused due to erythematous gastritis. In histopathology findings, chronic gastritis of antrum was found in 143 cases which constituted 95%. The pangastritis rate was 85%, common gastritis of antrum was atrophic type which constituted 80% of the patients, common gastritis of fundus was superficial type which was in 62% of patients, and intestinal metaplasia of stomach was seen in 5% of patients. From biopsy, helicobacter Pyroli in gastric antrum infection rate was 85%, Helicobacter Pyroli in gastric fundus infection rate was 40% and Helicobacter Pyroli in corpus of stomach infection rate was 5%. Conclusion: Chronic gastritis is caused by presence of Helicobacter pyroli. The most common site for Helicobacter Pyroli is the gastric antrum followed by fundus. In Chronic duodenal ulcers cases, the most common pathological abnormality is chronic superficial atrophic gastritis of antrum followed by pangastritis.