PROTECTIVE ROLE OF METHANOLIC FLOWER EXTRACT OF ALLAMANDA NERIIFOLIA HOOK AGAINST 1, 4 DICHLOROBENZENE (DCB)-INDUCED HEPATOTOXICITY

The present study was conducted to evaluate the protective role of methanolic flower extract of Allamanda neriifolia on 1, 4 dichlorobenzene (DCB)-induced hepatotoxicity in rat model. 1,4 DCB administered rats (300mg/kg/b.wt which was dissolved in 1ml of corn oil by intraperitonial injection for 45 days) were pre treated with methanolic flower extract of Allamanda neriifolia (300 mg / kg body weight) for 45 days and sacrificed after 1,4 DCB intoxication. Results showed that 1,4 DCB caused a marked rise in serum alanine aminotransferase (ALT), total cholesterol (TC), as well as marked decrease in serum total protein (TP), albumin (ALB), PCV, WBC, RBC, Hemoglobin and platelet compared to controls. However pre treatment with A.neriifolia methanolic flower extract produced a significant decrease in the ALT and total cholesterol level and an increase in total protein, albumin and hematological parameters compared to DCB alone group. Taken these data together, it can be concluded that natural plant components such as A.neriifolia flowers could protect the liver against dichlorobenzene (DCB)-induced liver toxicity. Keywords: Allamanda neriifolia, 1, 4 Dichlorobenzene, methanolic extract, Hepatotoxicity