FORMULATION AND EVALUATION OF ATENOLOL FLOATING MICROSPHERES

The purpose of present work was to formulate and evaluate atenololtartrate floating microspheres. Floating Microspheres concept was applied to increase the gastric residence of the dosage form. The Floating Microspheres were prepared by emulsification solvent diffusion technique. The best batch exhibited excellent floating time as well as release at desired time. The particle size was controlled by changing polymer concentration, rpm and temperature. Polymers used for the preparation were Ethyl cellulose and HPMC. This approach suggested the use of floating microsphere to avoid the side effects. Keywords: Microspheres, Atenololtartrate, Ethyl cellulose, HPMC.