Exploring Antioxidant Potential of Some Common Marketed NonSteroidal Anti-Inflammatory Drugs

Considerable controversy exists on the effect of NSAIDs on the oxidative status. Despite being held pro-oxidant in few instances, there are many studies which have commented on the antioxidant effect of NSAIDs and its relevance and beneficial utilization in clinical set-up. The present study probed into the antioxidant potential of some common marketed NSAIDs in in-vitro set up using DPPH and Nitric oxide radical scavenging assay. Nitric oxide radical scavenging procedure showed maximum scavenging activity for paracetamol and mefenamic acid, followed by aspirin. Results from DPPH assay showed maximum scavenging activity from aspirin followed by ibuprofen. Other NSAIDs also showed considerable radical scavenging activity indicative of antioxidant potential.