BIOCHEMICAL STUDIES OF RATS AFTER BONE IMPLANTATIONS OF MATERIALS ON THE BASE OF TTCP/ DCPA, TARTARIC OR ASCORBIC ACIDS

The study aimed to evaluate hematological levels of markers of bone turnover in rats with calvarial defects filled with modified calcium phosphates cements. Cements were synthesized basing on TTCP/DCPA, carboxylic acids, xanthan gum and glycerin. Total and bone alkaline phosphates, osteocalcin, and their relation with oxidative stress (malondialdehyde) were studied. No differences in the markers levels were observed between the groups with implants. The level of free radicals was significantly increased in all groups. The obtained data might be useful in future experiments with new bone implants.