PHARMACOKINETICS OF CIPROFLOXACIN IN PIGS AFTER SINGLE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONJournal: TRADITION AND MODERNITY IN VETERINARY MEDICINE (Vol.2, No. 2)
Publication Date: 2017-10-01
Authors : Dimitrichka Dimitrova Sofiya Ivanova Metodi Petrichev;
Page : 9-16
Keywords : ciprofloxacin; pharmacokinetics; pigs.;
The pharmacokinetics of ciprofloxacin in pigs after single intravenous or intramuscular application was followed out. Blood concentrations were assayed using HPLC with UV-detection. By means of the TopFit, v. 2.0. software, the pharmacokinetic parameters were calculated by two pharmacokinetic models – compartmental and non-compartmental. After i.v. application, the respective values of calculated pharmacokinetic parameters were as followed: t1/2α = 0.54 h; t1/2β = 5.92 h and t1/2β = 5.76 h; MRT = 8.74 h and MRT = 8.41h; AUC0= 23.14 µg.h/ml and AUC0= 22.24 µg.h/ml; Vss= 4.87 l/kg and Vd(area) = 5.14 l/kg. After i.m. application of ciprofloxacin, the respective values of calculated pharmacokinetic parameters were as followed: t1/2α = 0.46 h; t1/2β = 4.83 h and t1/2β = 4.61 h; MRT = 9.89 h and MRT = 9.68 h; t1/2abs. = 0.56 h; MAT = 1.15 h and MAT = 1.12 h; Cmax = 0.714 µg/ml and Cmax = 0.625 µg/ml; Tmax= 0.76 h and Tmax= 0.88 h; AUC0= 17.630 µg.h/ml and AUC0= = 16.835 µg.h/ml; F = 76.23% and F = 75.69%.
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