CORRELATION OF GAMMA GLUTAMYL TRANSFERASE AND HIGH DENSITY LIPOPROTEIN IN TYPE 2 DIABETIC SUBJECTS

Background: Considering that serum gamma-glutamyl transferase (GGT) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of type 2 diabetes worldwide, the aim of this study was to assess the association between serum GGT concentrations and High Density Lipoprotein In Type 2 Diabetic Subjects Methods: The present observational case control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Hospital Hyderabad/Jamshoro from October 2014 to September 2016. The materials for the present study were the diagnosed cases of type 2 DM. 100 diagnosed cases of T2DM and 100 non-diabetic subjects- taken as control, were selected by non-probability (purposive) sampling according to inclusion and exclusion criteria. Inclusion criteria were – diagnosed cases of type 2 DM, of >5 years duration, not taking anti- hyperlipidemic drug agent, age ≥40 years without history of cardiovascular disease. Diabetic subjects with urinary tract infections (UTI), Cardiac failure, pregnancy, diuretics, alcohol, chronic kidney disease (CKD), liver disease and smokers were excluded. Results: Age of controls and cases was noted as 52.23±6.21 and 51.29±4.97 years respectively (P=0.94) (table 1). Of 100 controls and 100 cases, male were 62 and 61 and female were 38 and 39 respectively (X2= 0.21, P=0.51). Body weight, blood pressure, random blood glucose, HbA1c, serum creatinine, cholesterol, triglycerides, LDLc, HDLc and GGT Conclusions: The present study shows positive association of gamma glutamyl transferase with cholesterol, triglycerides and low density lipoprotein (LDLc) but negative association with high density lipoprotein (HDLc). Keywords: Gamma-Glutamyltransferase, High Density Lipoprotein, Diabetes Mellitus, Type 2