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Treatment of Alveolar Soft-Part Sarcoma with Bevacizumab: A Case Report and Review of the Literature

Journal: Sarcoma Research - International (Vol.1, No. 2)

Publication Date:

Authors : ; ;

Page : 1-3

Keywords : Alveolar soft-part sarcoma; Bevacizumab; Methotrexate;

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Abstract

Alveolar Soft-Part Sarcoma (ASPS) is a rare disease and accounts for approximately 0.5-1% of soft tissue sarcomas. While many localized ASPS in younger adults occur in the lower extremities, patients with advanced stages often present with lung and central nervous system metastasis. ASPS are strongly vascularized tumors and few cases, mainly pediatric patients, were reported to respond to anti-angiogenic therapy. We present a case of a 29-year old malepatient with stage IV ASPS with a primary lesion in his right lower leg and pulmonary and cerebral metastasis. After induction treatment (doxorubicin, methotrexate, bevacizumab) and radiotherapy to the cerebral metastasis and the primary site, the disease was stabilized by bevacizumab maintenance therapy over 10 months. Here, we discuss this case within the context of the current literature on ASPS and trials that include anti-angiogenic strategies to treat soft tissue sarcomas.

Last modified: 2018-02-05 19:17:59