Dislipidemia and Serum Level of Interleukin-22 in Hypertensive Patients with Concomitant Excessive Body Weight or ObesityJournal: Lviv Clinical Bulletin (Vol.4, No. 20)
Publication Date: 2017-12-28
Authors : Kovalyova O.; Ashcheulova T.; Kysylenko K.;
Page : 8-14
Keywords : dyslipidemia; excessive body weight; hypertension; interleukin-22; obesity;
Introduction. Hypertension is the most common chronic disease that has up to 20.0-30.0 % of the adult population of the planet. The presence of concomitant diseases, including obesity worsens the course and prognosis of Hypertension. Along with obesity, an important factor in the risk of cardiovascular events, is a lipid metabolism disorder. In recent years, the concept has been formulated, according to which in the pathogenesis of lipid metabolism disoder an important role is played by the inflammatory process, mediated by cytokines. Aim. The study is devoted to determining the parameters of the lipid metabolism and the serum level of interleukin-22, as well as the relationship between them, in patients with hypertension, depending on the presence of excess body weight or concomitant obesity. Materials and methods. 80 patients with hypertension were examined. All patients were divided into three groups: group 1 (n = 19; 23.8 %) - patients with hypertension whis normal body weight, group 2 (n = 30; 37.5 %) – hypertensive patients with excess body weight, group 3 (n = 31; 38.8 %) – hypertensive patients with obesity. The control group included 12 healthy individuals. Levels of serum interleukin-22 were studied by using set Bender Medsystems® Human IL-22 Platinum ELISA. Results. According to the results of the study, in patients with hypertension of the third group there is a maximum content of total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, atherogenic index, remnant cholesterol and apolipoprotein B. The minimum content of high-density lipoprotein cholesterol is observed in the second and third groups of patients with hypertension. When comparing the parameters of lipid metabolism in the main groups of patients with hypertension and the control group, a significant increase in all atherogenic parameters in the main groups was revealed (p < 0.001). These data suggest that dyslipidemia is directly or indirectly involved in the mechanism of increasing blood pressure and the development of hypertension. It was noted that in hypertensive patients with excessive body weight and obesity revealed basal hypercholesterolemia, hypertriglyceridemia, hypoalphacholesterolemia, increased cholesterol levels of low density lipoprotein and cholesterol of very low density lipoprotein, and also the disturbance of lipid metabolism tolerance in the postprandial period, which is manifested by an increase the content of total cholesterol, triglycerides, cholesterol of low density lipoprotein, cholesterol of lipoproteins is very low density and decrease cholesterol of high density lipoprotein. Conclusions. Thus, the data obtained may indicate an interleukin-22 hypertensive effect. And the presence of close correlation relations of the investigated cytokine with parameters of the lipid spectrum may indicate that it is involved in increasing the severity of lipid metabolism disorders.
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