Anti-DPPX-Encephalitis in A Patient with Cerebral Vasculitis and Connective Tissue Disease
Journal: Journal of Neurological Research And Therapy (Vol.2, No. 3)Publication Date: 2018-01-12
Authors : Eva Krause; Timolaos Rizos; Mike Sohendra; Norbert Blank; Hans-Michael Meinck; Silvia Schönenberger; Simon Nagel;
Page : 1-6
Keywords : DPPX; encephalitis; vasculitis; connective tissue disease;
Abstract
Since the first description in 2013, 39 cases of anti-DPPX-encephalitis have been described. Main features of this autoimmune encephalitis characterized by antibodies against the potassium-channel-associated regulatory protein DPPX are gastrointestinal symptoms, cognitive dysfunction and signs of CNS hyperexcitability. While the majority of patients responds to immunotherapy relapses are frequent and often successfully treated with rituximab.
Here we report another case of anti-DPPX-encephalitis presenting with the above mentioned triad. However, this is the first case of anti-DPPX-encephalitis in the context of a connective tissue disease combined with cerebral arteriopathy along with brain parenchymal lesions that we interpreted as a secondary, CTD-associated cerebral vasculitis. While the latter resolved under immunosuppressive treatment, comprising glucocorticosteroids, cyclophosphamide, rituximab and plasmapheresis, deterioration of the CTD and multiple infectious complications finally led to the patient's death. As histological evidence for cerebral vasculitis is lacking, other differential diagnoses for the observed cerebral arteriopathy, especially reversible cerebral vasoconstriction syndrome, have to be considered.
Other Latest Articles
- Effect of Different Media Combination on Growth and Biomass Production of Oil Palm (Elaeis. guineensis) Seedlings
- Potential Impact of Salt Stress on Male Reproductive Development of Glycine Max (L.) Merr. (Soybean)
- Changes in Statistics of Malignant Neoplasms of Central Nervous System Excluding Brain (ICD-10: C70, C72) In the Lower Silesia Region of Poland in the Years 2006-2012
- Murky Water: Cyanobacteria, BMAA and ALS
- Evaluation of a Stroke Protocol Using Computed Tomography Angiography for the Evaluation of Acute Ischemic Stroke Patients
Last modified: 2018-02-10 14:47:25