Ruthenium(III) Thiosemicarbazone Complexes: Synthesis, Characterization, DNA Binding, Antibacterial, In vitro Anticancer and Antioxidant Studies
Journal: DJ Journal of Engineering Chemistry and Fuel (Vol.1, No. 1)Publication Date: 2016-01-02
Authors : K Sampath C Jayabalakrishnan;
Page : 40-53
Keywords : Ruthenium complexes; Methyl thiosemicarbazones; Antioxidant; MCF-7; DPPH radical.;
Abstract
Ruthenium(III) complexes of the type [RuBr2(PPh3)2L] (where L = monobasic bidentate thiosemicarbazone ligand) have been synthesized. Various physico-chemical and spectral techniques were used to determine the structural features of the complexes. Absorption spectroscopy was used to investigate DNA binding of the complexes. It indicated that the complexes bind to DNA through intercalation. The complexes have shown significant antibacterial activity than the ligands against a panel of bacteria. The efficiency of the complexes to arrest the growth of MCF-7 cancer cell line has been studied. This was done along with the cell viability test under in vitro conditions. Finally, antioxidative property of the complexes against DPPH radical was investigated
Other Latest Articles
- Ultrasonic Investigation of Hydrogen Bonded Complexes of Aniline with CHCl3 and CH2Cl2
- Sorption and Desorption of UO2 2+, Th4+, Eu3+, Ru3+ and Fe3+ on the Synthetic Analogue of Nepheline
- Quantum Mechanical Studies on Free Energy of Solution of some Vitamins and their Correlation with Bioavailability
- The Asymptotic Behavior of the Titchmarsh-Weyl m-function for a Dirac System on the Line
- Exam Results Fit to a Normal Distribution
Last modified: 2018-02-15 13:07:55