Synthesis, Spectral Characterization, Computational Studies and Antimicrobial Activities of Imidazole Derivatives

The imidazole derivatives are synthesised and characterized by FT-IR, NMR and mass spectral analysis. The optimized geometrical parameters, HOMO - LUMO energy levels and Molecular Electrostatic Potential (MEP) were carried out. The imidazole derivatives (1-4) against bacterial strains and fungal strains were carried out by using Agar well diffusion method and serial dilution method. The bacterial strain such as Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, Klebsiella pneumonia, Pseudomonas, Auruginosa, Escherichia coli and Candida albicans, Candida-6, Rhizopus, Aspergillus flavus, Aspergillus niger and Mucor fungal strains are used for this study. Fluconazole and Ciprofloxacin are used as standards (positive control) for fungal and bacterial strains, respectively