Allele and Genotype Frequency of Polymorphous Variants of ATIIR1 and CYP11b2 Genes in Patients with STEMI with the Presence of Anxiety and Depressive Conditions

The purpose of the study is to determine the link between CYP11B2 (-344ТС) and ATIIR1 (A1166C) polymorphisms and their combinations with anxiety and depressive disorders (ADD) in patients with ST-elevation myocardial infarction (STEMI). Materials and methods. 85 patients with STEMI were examined, 68 (80%) men and 17 (20%) women, with the average age (58,94±10,16) years old. We used the questionnaire of HADS (Heart Anxiety and Depression Scale) and the Tailor questionnaire for objectification of existing alarming and depressive disorders which are risk factors of a myocardial infarction. Testing of patients allowed allocating two groups: the first one was with normal or limit implication of alarm it made up 48 patients, and the second group had 37 patients with the increased level. Allele polymorphism Т344С of CYP11B2 and A1166C of ATIIR1 gene were determined by polymerase chain reaction in real time. Statistics was obtained thanks to software package Statistica 8.0 (Stat SoftInc, USA), Microsoft Office Exсel 2003. ADD were diagnosed with the help of Tailor questionnaire and Heart Anxiety and depression Scale (HADS). All the patients were divided in two groups – with ADD and without them. Results and discussion. Observed and estimated frequencies of investigated polymorphisms were in tune with Hardi-Weinberg equilibrium (P>0,05). Relative risk of STEMI in the presence of ADD is associated with TT-genotype of CYP11B2 gene (-Т344С polymorphism), OR 0,33, 95% CI [0,13-0,91], Р=0,05, Т-allele, OR 1,94, 95% CI [0,04-3,56], Р=0,03, combination of 1166АА-344ТТ-variants, Р=0,049. 344С-allele of CYP11B2 gene can be considered as protective factor: OR 0,52, 95% CI [0,28-0,96], Р=0,03. Conclusions. 344T-allele and 344TT-polymorphism of CYP11B2 gene is associated with higher relative risk of STEMI in the presence of ADD. In patients with STEMI and ADD more often appears the combination of 1166АА-344ТТ-polymorphous variants of ATIIR1 and CYP11B2 genes. We found no associations between polymorphous variants of ATIIR1 gene and ADD in patients with STEMI.