THE ANTI-ALLERGIC ACTIVITY OF BUCHANANIA LANZAN SPRENG. LEAVES ON MAST CELL MEDIATED ALLERGIC MODELS

Objectives: The purpose of this study was to assess the anti-allergic action of Methanol extract of plant Buchanania lanzan Spreng. leaves on mast cell intermediated allergic models. Materials and methods: The methanol extracts of plant Buchanania lanzan spreng. Leaves protecting effect is checked in pruritus and anaphylaxis models of the acute phase of allergic reactions induced by compound 48/80. The mast cell degranulation and histamine release from blood induced by compound 48/80 is determined. Results: The methanol extract of Buchanania lanzan Spreng. Leaves produced noteworthy inhibition of pruritus and anaphylaxis induced by compound 48/80 and Dose-dependent noteworthy Stabilization of mast cell membrane is also observed in compound 48/80 induced mast cell activation. It is observed that the dose-dependant decrease in the release of histamine. Conclusion: These results show the methanol extract of plant Buchanania lanzan Spreng. Leaves by inhibition of histamine release from mast cells have efficient anti-allergic property. Keywords: Compound 48/80, Anti-allergic, Mast cells, Buchanania lanzan, Antihistaminic.