FORMULATION AND EVALUATION OF BUOYANT MICROSPHERES OF NIZATIDINE BY SPRAY DRYING TECHNIQUE
Journal: Indian Drugs (Vol.55, No. 01)Publication Date: 2018-01-29
Authors : Palekar N. G. Keny R. V.; Jagtap V. A.;
Page : 81-83
Keywords : ;
Abstract
The objective of the present investigation was to formulate multiparticulate buoyant dosage form of nizatidine, a H2-receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, colonic metabolism of nizatidine favors, development of gastro retentive floating dosage form. Buoyant microspheres of nizatidine were prepared by spray drying technique using hydroxylpropyl methylcellulose and ethylcellulose as the rate controlling polymers. The prepared multiparticulate system were evaluated for various physicochemical parameters such as flow properties, in vitro buoyancy (floating lag time, total floating time), swelling studies, drug content and in vitro drug release. The shape and surface morphology of prepared microspheres were characterized by scanning electron microscopy. The formulated multiparticulate buoyant dosage form of nizatidine may be used in clinic for prolonged drug release in stomach for at least 12 hrs, thus improving the bioavailability of the drug during ulcer treatment.
Other Latest Articles
- STUDY OF KEY STAKEHOLDERS FOR THEIR KNOWLEDGE, ATTITUDE AND PRACTICE ON ADVERSE DRUG REACTION REPORTING IN TERTIARY CARE HOSPITALS IN JAIPUR, INDIA
- ETHICAL DIMENSIONS OF WILLINGNESS TO PAY FOR MEDICAL CARE IN BULGARIA
- EFFECTS OF MECHANICAL VIBRATION FORCE ON TOOTH MOVEMENT; FINITE ELEMENT ANALYSIS
- LEVEL OF IMPLEMENTATION OF THE RESULTS-BASED PERFORMANCE MANAGEMENT SYSTEM IN THE DEPARTMENT OF EDUCATION DIVISION OF GAPAN CITY, PHILIPPINES
- EVALUATION OF ANTIOXIDANT, HYPOGLYCAEMIC, ANTIDIABETIC AND ALPHA AMYLASE INHIBITING ACTIVITIES OF SARGASSUM WIGHTII COLLECTED FROM THE EAST COAST OF INDIA
Last modified: 2018-02-21 14:50:34