A Mathematical Model on Vorinostat (Histone Deacetylase Inhibitor) in Combination with Radiotherapy

There are four main and most types of cancer treatments, which are surgery, chemotherapy, radiotherapy, and immunotherapy. In this paper, we consider cancer treatment by radiotherapy. Radiation therapy is a treatment procedure that uses radiation to kill tumor cells. The Histone deacetylases inhibitor (HDAC) Vorinostat (suberoylanilide hydroxamic acid or SAHA) combination with radiotherapy blocks cancer cell proliferation. In this study we developed and analyse Mathematical model for tumor growth and histone deacetylase inhibitor, in combination with radiotherapy then we analyse the stability of equilibria. And fitting Patient 1 data to numerical simulation for locally weighted smoothing linear regression. Citation: G. Komahan, AVVM Sri Pushpam College, Poondi; R. Lalitha ,AVVM SRI PUSHPAM COLLEGE,POONDI. "A Mathematical Model on Vorinostat (Histone Deacetylase Inhibitor) in Combination with Radiotherapy." Global Research and Development Journal For Engineering 33 2018: 35 - 39.