SYNTHESIS AND ANTIMICROBIAL STUDY OF SOME NEW PICRIC ACID DERIVATIVES

In the present study, a new series of picric acid derivatives including their Schiffs bases were synthesized and characterized by their physical (m.p., Rf value), analytical (CHN) and spectral (UV-Visible, IR,1HNMR, MS) data. The synthesized compounds were screened for antimicrobial activity by paper disc diffusion method against four different strains of Gram positive (Bacillus subtilis, Staphylococcus aureus)and Gram negative bacteria (Eschericia coli, Pseudomonas aeruginosa) and against two fungal strains(Candida albicans, Aspergillus fumigates). All the compounds showed antibacterial activity at the tested dose but were considerably less as compared to the standard drug ciprofloxacin. The antifungal activity was also found to be very less when compared to the standard drug ketoconazole for all the synthesized compounds. However, among the synthesized compounds Schiffs bases of picric acid showed better activity than that of parent compounds.