SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT STRATEGIES FOR EFFECTIVE DELIVERY OF POORLY WATER SOLUBLE DRUGS BY NANO FORMULATIONS AND SOLID DISPERSIONS

For the ancient few years, there has been a substantial research done on diverse methodologies for poorly water soluble and lipophilic drugs. More in modern times voluminous molecules cannot be distributed due to low solubility. Now a day frequently, particulate vesicle systems such as nanoparticles, liposomes, microspheres, niosomes, pronisomes, ethosomes, and proliposomes have been used as drug carriers. Drug delivery designates the technique and methodology to conveying medications or drugs. Nanoparticles have been refining the beneficial effect of drugs and minimize the side effects. Basically, Nanoparticles have been arranged by using various techniques as such dispersion of preformed polymers, polymerization of monomers and ionic gelation or coacervation of hydrophilic polymer. Nano particulate formulation approaches could be applied instead as alternative. As in the case of solid dispersions, efficacious permeation of these generally rather difficult to develop approaches into commercial drug product development has taken. This review tries to gives viewpoint for both Nano particulate and solid dispersion technologies. Keywords: Nanoparticles, solid dispersions, coacervation, polymerization, drug delivery