FEATURES OF BLOOD OXYGEN TRANSPORT AND PROOXIDANT-ANTIOXIDANT STATE DEPENDING ON THE CHARACTER OF TUBERCULOSIS PROCESS

Background. In conditions of tuberculosis inflammation decompensation occurs in the system of lipid peroxidation - antioxidant protection, an important role in which belongs to the mechanisms of oxygen transport by blood. Purpose of the study. To study the features of blood oxygen transport and prooxidant-antioxidant state, depending on the character of the tuberculosis process. Material and methods. A total of 120 patients with various types of the tuberculosis process in the lungs were examined. In the first 10 days, after admission of the patient to the hospital, 10 ml of blood was taken from the ulnar vein under the restored outflow. Evaluation of blood oxygen transport was performed within an hour after venous blood sampling. The rest of the blood was separated by centrifugation into plasma and erythrocyte mass, which were stored at -80° C with the subsequent measurement of prooxidant-antioxidant status within one month. Results. The blood oxygen transport and prooxidant-antioxidant balance were analyzed for different types of the tuberculosis process. The most significant increase in p50 was observed in the advanced tuberculosis process (by 13.06% (p <0.05), in the presence of destruction in the lung tissue (by 13.06% (p <0.05).), in the presence of bacterial excretion (by 10.07% (p <0.05).) and in the multiple drug resistance of mycobacterium tuberculosis (by 9.89% (p <0.05). This was accompanied by more pronounced activation of lipid peroxidation processes and a decreased antioxidant reserve. Conclusions. Changes in the blood oxygen transport as well as the activity of free radical oxidation in pulmonary tuberculosis depend on the extent of the tuberculosis process, the presence of destruction in the lung tissue, bacterial release and the presence of multiple drug resistance. The revealed features justify the administration of antioxidant therapy and drugs promoting tissue oxygenation.