PREPARATION AND CHARACTERISATION OF TORSEMIDE MICROCAPSULES

Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long term medical condition in which the blood pressure in the arteries is persistently elevated. Microencapsulation is a process of applying relatively thin coatings to small particles of solids or droplets of liquids and dispersions. It provides the means of converting liquids to solids, of altering colloidal and surface properties, of providing environmental protection and of controlling the release characteristics or availability of coated materials. Batches of microcapsules were prepared by ionotropic gelation method which involved reaction between sodium alginate and polycationic ions like calcium to produce a hydrogel network of calcium alginate. Sodium alginate and the mucoadhesive polymer were dispersed in purified water (10 ml) to form a homogeneous polymer mixture. Torsemide microcapsules were prepared with Eudragit RL 100 and Eudragit RS 100 by using solvent evaporation method.Preformulation and evaluation studies were performed for all the microcapsules. The in vitro dissolution studies were performed using USP type I dissolution apparatus at 100 rpm. Invivo clinical studies were conducted. Microcapsules prepared with ion tropic gelation method T-F7 formulation shown maximum drug release. DSC and FTIR studies were also performed. Keywords: Hypertension, Torsemide microcapsules, ionotropic gelation method.