Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat
Journal: Journal of Advanced Laboratory Research In Biology (Vol.3, No. 3)Publication Date: 2012-07-01
Authors : Alamgir Z. Chowdhury; M. Ibrahim Hossain; Sabir Hossain; Sohel Ahmed; Tanzila Afrin; Nurul Karim;
Page : 175-180
Keywords : Momordica charantia; Antidiabetic effect; Streptozotocin; Hexose monophosphate shunt;
Abstract
The hypoglycemic effect of Momordica charantia (Karela) has been reported from many laboratories. To our knowledge, the underlying biochemical mechanism of action of this important clinical effect has not been reported. During the course of investigation of this aspect of the herbal fruit, it was reported from our laboratory that ethanolic extract of Momordica charantia suppressed gluconeogenesis in normal and streptozotocin (STZ) induced diabetic rats by depressing the hepatic gluconeogenic enzymes fructose-1,6-bisphosphatase and glucose-6-phosphatase. The herbal extract had also enhanced the activity of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of hexose monophosphate shunt (a pathway for the oxidation of glucose).
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