DYNAMICS OF TROMBOXAN B2 IN PATIENTS WITH BRONCHIAL ASTHMA, COMBINED WITH NON-ALCOHOLIC STEATOGEPATITIS DURING TREATMENT

Introduction. Polymorbidity is a burning issue of modern medicine. It is presented as a combination of bronchial asthma (BA) with chronic non-alcoholic steatohepatitis (NASH). The determining pathogenetic factor for both diseases is inflammation, which is implemented with many cells and mediators. One of these mediators is products of arachidonic acid metabolism ? thromboxane, which biological role is to strengthen the platelet aggregation. Activation of platelet adhesion and aggregation promotes microrheological violations. Our aim was to examine the contents of thromboxane В2 (TхВ2) and the state of platelet aggregation in patients with a combination of BA and NASH. Material and methods. We examined 68 patients (the mean age (34.5 ± 3.2) years) with moderately severe BA. In 35 patients with ВА diagnosed NASH. The control group consisted of 29 apparently healthy persons in the same age range. Results and discussion. TxB2 content in the blood serum of patients with BA was (1403.7 ± 516.2) pg/ml and 6 times (p