PEGylatedPolylactide Micelles for Controlled Drug Delivery

Olylactide (PLA) is a type of widely used synthetic polymers with excellent biocompatibility and biodegradability [ 1 ]. Moreover, PLA with adjustable mechanical and physical properties, excellent workability, and low immunogenicity has been approved by the US Food and Drug Administration (FDA) for multiple medical applications clinically, such as drug delivery [ 2 , 3 ], tissue engineering [ 4 , 5 ], postoperative anti-adhesion [ 6 , 7 ], medical device [ 8 ], and so on. PLA can be synthesized through the ring-opening polymerization (ROP) of lactide efficiently, which is catalyzed by a wide variety of organometallic catalysts [ 1 ]. As depicted in Figure 1, lactide acid is a chiral molecule existing in L and D isomers.