Clinical Manifestations of Treatment Naïve HIV Infected Patients in Pakistani Population

The Human Immunodeficiency Virus (HIV) infection is a global burden with the most prevalence in sub-Saharan Africa. Although the prevalence of HIV in Pakistani population is low but it is ranked as a high risk country. The current study was designed to investigate the clinical manifestation of 600 HIV untreated patients from several major cities of Punjab, the largest province of Pakistan. These patients were tested for other co-infections like Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Tuberculosis (TB). CD4+ and CD8+ T lymphocytes profile of all the subjects was also determined by fluorescence activated cell sorting (FACSCalibur) using BDTritestCD4/CD8/CD3 antibodies. The results showed that in all untreated HIV subjects, CD4+ T lymphocytes were decreasing with the disease progression, while the primary level of CD8+ T lymphocytes cells was decreased but later on it kept increasing. The ratio of CD4+ T lymphocytes /CD8+ T lymphocytes was also decreased with disease progression.