INDOLES AS THERAPEUTICS OF INTEREST IN MEDICINAL CHEMISTRY

Indole is a valuable compound which has becomeprominent in medicinal chemistry because of its variousbiological activities. Indole ring is present in various marineor terrestrial natural compounds, which have useful biologicalproperties. In last few years it was reported that indole, itsbioisosters and derivatives had antimicrobial activity againstgramnegative, grampositive bacteria and yeast candidaalbicans antimicrobial activity. A large number of efforts were made to synthesizedifferent heterocyclic compounds and their derivatives in thepast decode and were found to possess promising antitumor, anticonvulsant, antimicrobial anti tubercular and anti diabetic activities. Although indole moiety is very small but isfascinated by scientists because of the diverse biologicalactivities by not only indole but its various substitutedderivatives as well. This revisers is focused on the indole andits derivatives that are now in development. This review brings about an overview of novel drug molecules of indole and also urges to synthesize moremoieties for better enhanced biological activity. Keywords: Indole, Antimalarial, Anticancer, Antimicrobial, Antihypertensive