The Effect of Surfactant on Developed Ophthalmic Drug Delivery System for the Delivery of Antifungal Drug in Posterior Segment of Eye

Eye is a complex organ; drug delivery to the posterior segment poses significant challenges due to its unique anatomical and physiological barriers. The surfactant based drug delivery system enhances the bioavailability by increasing drug solubility, prolonging pre-corneal retention and enhancing permeability. So by considering the advantages of surfactant based drug delivery system, this study were carried out on Voriconazole; a lipophilic category antifungal drug. The work describes usefulness of a surfactants based drug delivery system for targeting topically applied drug to the posterior segment of the eye. The system was formulated using Span 80 with (edge activator) Tween 80 by using ethanol injection method. A 32 full factorial design was used to study the effect of two independent variables, namely, the concentration of Span 80 and the concentration of Tween 80. For optimization of formulation drug content and excised goat eye permeability were taken as response variables. Formulation batch containing 20:80 (Span 80: Tween 80) shown better corneal permeability performed on goat's eye and higher drug content amongst all formulated batches. Therefore, the study confirmed that surfactant based ocular drug delivery systems shows good permeability for ocular delivery of Voriconazole and it can be used to deliver drugs to the posterior segment of the eye.