NEUROENDOCRINE ASPECTS OF THYMUS HORMONE ANA-LOGUES APPLICATION

Immune system cells express receptors to neuropeptides and hormones (GH, PRL, PG, CRH, ACTH, TRH, TSH, β-endorphin, VIP, Met5-Enkephal). The cells of the immune system also produce hormones (ACTH, GH, PRL, TRH, CGGT, FSH and LG). They are isolated by activated lymphocytes and act as messengers between the endocrine and immune system, and have both auto and paracrine functions. The objective of the study is to detect the neuroendocrine effects of the synthetic analogue of the modified fragment of the biologically active part of the thymus hormone molecule thymopoietin (Immunophane). Clinical model was selected from the patients with CHF.The research was conducted on the basis of Ivano-Frankivsk Regional Clinical Hospital in 2009. We examined 45 patients with CHF FCIII-FKIV: the main group included 25 people, the control one - 20 people. The patients'average age is 53 ± 6.6 years old. The patients in both groups were randomized by age, sex, and the duration of the disease. Conclusion. The conducted pilot investigation initiated an extensive mechanism study of the synthetic analogue of the modified fragment of the thymuspoetin molecule (immunophan), biologically active part, on the neurodendocrine system of the body. It has been established that this medication, together with immunocorrective action, has an effect on the level of ACTH, cortisol, prolactin, STH, TTH, free thyroxin and β-endorphin production, balancing their correlation. It is not advisable to use this drug in case of auto-immune thyroiditis.