GENDER FEATURES OF IMMUNE DISORDERS IN METABOLIC SYNDROME

The metabolic syndrome (MetS) has emerged as an important cluster of risk factors for atherosclerotic disease. Common features are central (abdominal) obesity, insulin resistance, hypertension, and dyslipidemia, namely high triglycerides and low high-density lipoprotein cholesterol. Many studies showed the high prevalence of metabolic syndrome among postmenopausal women, which varies from 32.6% to 41.5%. Chronic inflammation and immune system disturbances may represent a triggering factor in the origin of the metabolic syndrome: stimuli such as overnutrition, physical inactivity, and ageing would result in cytokine hypersecretion and eventually lead to insulin resistance and diabetes in genetically or metabolically predisposed individuals. Aim of study: evaluation of gender features of immune parameters in patients with metabolic syndrome. Materials and methods. 130 patients with MetS were observed – 24 males and 106 females. All females were divided into two groups: 80 patients in physiological menopause and 26 without it. 21 practically healthy females without signs of MetS were the control group. The immunological parameters of 1-st level were studied. Results. MetS in menopausal woman is characterized of increase of Ig A, Ig G and Ig M in blood plasma and growth of pathological middle and low-molecular immune complexes. Physiological high-molecular complexes were without changes. Conclusion. The features of menopausal metabolic syndrome are high levels in serum of Ig A, Ig G and Ig M, and increased concentration of middle and low-molecular circulating immune complexes.