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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACECLOFENAC BY USING ISPAGHULA HUSK POWDER AS NATURAL SUPER DISINTEGRANT

Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 03)

Publication Date:

Authors : ;

Page : 1793-1801

Keywords : Aceclofenac; Ispaghula husk powder; FTIR; disintegration test; dissolution test.;

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Abstract

Fast disintegrating tablets (FDTs) are meant for administration to the patients who cannot swallow, such as elderly, stroke victims, bedridden patients, patients affected by renal failure, and the patients who refuse to swallow, such as pediatric, geriatric, and psychiatric patients. The present study is aimed to prepare orally disintegrating tablet of a model drug – Aceclofenac, using Ispaghula powder as natural super disintegrant, to conduct incompatibility studies by using Fourier-transform infrared spectroscopy (FTIR), to evaluate the prepared tablets for weight variation, friability, hardness, disintegration and dissolution tests, and also to compare the results with tablets prepared by using synthetic disintegrate crosspovidone. Post hoc analysis revealed that all the formulations have shown the results of pre-compression as well as post compression parameters within the acceptable limits and FTIR studies showed that there are no incompatibilities between the drug and excipients used in the formulation. Thus the study leads that Plantago ovata (Ispaghula) can be successfully used as natural super disintegrate. Keywords: Aceclofenac, Ispaghula husk powder, FTIR, disintegration test, dissolution test.

Last modified: 2018-04-07 23:39:35