THE ANTIOXIDANT EFFECTS OF GRAPE SEED OIL ON RETINYL PALMITATE STABILITY

Retinyl palmitate (RP) is recognized as a potential substance for the prevention and treatment of photoaging and skin inflammation. However it is also associated with skin irritations and extreme photo instability. In order to improve its skin delivery, photostability and to avoid undesirable topical side effects the RP was nanoencapsulated using the interfacial deposition of preformed polymer using the grape seed oil (GSO) a potential antioxidant as oil phase. Dynamic light scattering showed droplet size close to 214 nm, polydispersity index close to 0.18 and zeta potential with negative charge. Scanning electron microscopy exhibits spherical shape nanocapsules with a diameter of 205.6 ± 62.2 nm in good agreement with hydrodynamic diameter of nanocapsules in the dispersions. Presence of GSO as oily phase in nanocapsules increases the RP stability as longer than 180 days. It was observed a sustained and controlled RP dermal release by the analysis of RP in the donor and receptor phase by using vertical Franz diffusion cells. Key word: Retinoid, Polymeric nanocapsules, Stability, Skin permeation, Antioxidant.