FORMULATION AND EVALUATION OF CEFADROXIL MUCOADHESIVE TABLETS

Cefadroxil was formulated as mucoadhesive tablets to improve its bioavailability. Xanthan Gum, Guar Gum , Chitosan and Acritamer 940 were selected as polymers. Various formulations were prepared by using these polymers alone Ex vivo permeation study of Cefadroxil drug solution through the porcine mucosa was performed using franz diffusion cell and the flux value was found to be 400.51 µg.hr-1cm-2, 0.410 cm/hr. The pre-compression blend of Cefadroxil mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr's index and hausner's ratio and all the results indicated that the blend was having good flow nature and better compression properties. The swelling studies were performed for the formulations which were shown desired drug release. Peak detachment force (N) and work of adhesion were calculated and they were found to be good. F5 formulation was showing 94.9% drug release in 8 hrs and following Korsmeyer peppas mechanism with regression value of 0.993. F5 formulation was showing maximum flux value of 382.445 (µg.hrs-1cm-2) and permeability coefficient value was 0.422 (cm/hrs). So based on the results F5 was found to be an optimised formula and concluded that Cefadroxil can used as mucoadhesive tablets. Keywords: Mucoadhesive tablets, Cefadroxil, Bioadhesive polymers, Flux, Permeability coefficient.