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STUDY ON RISK ASSOCIATION OF SERUM VITAMIN D DEFICIENCY AND SOLID MALIGNANCIESSanta A, Rama Mani G* , Munta Anil Kumar, Krishna Mohan MVT , Jyosthna V & Senthil Rajappa

Journal: Indian Journal of Medical Research and Pharmaceutical Sciences (Vol.5, No. 4)

Publication Date:

Authors : ; ;

Page : 130-23

Keywords : serum Vitamin D; Deficiency; Solid Tumors and risk association;

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Abstract

Background and objectives: Vitamin D involved in various conditions including signaling pathways that affects the numerous cellular processes. However, according to the recent observations, low level of serum vitamin D is associated with tumorogenesis. Materials and Methods: The study includes 426 individuals of solid malignancies along with age and sex matched healthy controls (n= 426). The serum vitamin D level was estimated by electrochemiluminescence method and the data analyzed statistically. Results: The mean of serum vitamin D in solid malignancies and control groups were 15.53ng/mL and 18.15ng/mL respectively. Vitamin D deficiency was found in the individuals of 380 cases of solid tumors (89.2%) and 355 of the control group (83.3%) and representing the risk association towards the disease (OR=1.65). The Sub group analysis also revealed that low vitamin D levels, i.e., less than 10 ng/mL was observed in all other categories of solid malignancies like breast, lung, gynecological, prostate, gastrointestinal, head & neck, sarcomas (bone & soft tissue) and various other solid malignancies. Conclusion: The serum vitamin D deficiency is significantly associated with all the categories of solid tumors in comparison to control and maintaining the adequate levels may reduce the risk and their associated overall outcomes.

Last modified: 2018-04-10 19:20:36