SYNTHESIS OF A NOVEL STEROIDAL HETEROCYCLIC AS EFFECTIVE ANTIMICROBIAL AGENT

The introduction of an isoxazole ring system in a steroidal moiety may leads to the formation of drugs of medicinal importance. In view of therapeutic importance of these steroidal heterocycles, we report the synthesis of cholest-4-eno[2,3-d]isoxazole from cholesterol. The synthesized compound were screened for their antifungal activity by Serial plate dilution method, using Fluconazole as standard drug against dimorphic fungal strain C. albicans and other fungal strain A. niger in the concentrations of 25, 50 and 100 ?g/ml in DMF (solvent). Synthesized compounds showed good antibacterial activity. {*Corresspondence to Mr. Latit Kumar Pareta, Assistant Professor, Department of Pharmaceutical Chemistry, Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur, Rajasthan, India - lalitpareta@gmail.com}