Improvement in lipid profile of the patients with saxagliptin as add on therapy in patients of uncontrolled type 2 DM who were on metformin alone

Introduction: Diabetes is characterized by chronic hyperglycemia and deranged carbohydrate, lipid and protein metabolism. This study shows an improvement in lipid profile (TC, TG, LDL and HDL) with saxagliptin in patients of uncontrolled type 2 diabetes mellitus (T2DM) who were previously on metformin monotherapy. Materials and Method: A total of 30 patients with uncontrolled diabetes were enrolled, who were on metformin 1500 mg daily. Patients were given metformin 500 mg twice a day and saxagliptin 2.5 mg once a day. Patients were followed up at 1st, 3rd and 6th month and lipid profile (TC, TG, LDL and HDL) was estimated. Results: The mean age ± SD in males and females was 61.42yrs ± 6.99 and 55.93yrs ± 5.74 respectively. The mean change in value from baseline at 24 weeks was TC= 9.66%, TG= 9.40%, LDL= 14.87%, HDL= 5.63%. A highly significant difference was seen at 0 v/s 1, 0 v/s3 and 0 v/s 6 months in lipid profile values. Conclusion: Saxagliptin has shown an improvement in lipid profile (TC, TG, LDL, HDL) during 6 months of treatment duration in patients of T2DM.