Microbiological profile and sensitivity pattern in neonatal sepsis in a tertiary care Centre in Western UP

Objective­: To determine the Microbiological Profile and Sensitivity Pattern in Neonatal Sepsis in the Nursery of a Tertiary Care Centre in Western UP. Method: A prospective observational study was conducted in the Department of Pediatrics, Subharti Medical College, Meerut, over one year (October 2015 - October 2016) on 240 patients, after clearance from the ethical Committee. All babies admitted in NICU or Nursery with risk factors or clinical features of neonatal sepsis or those evaluated for sepsis during their admission period, were included in the study, after taking written consent from parents. A detailed history and thorough examination was done of all babies enrolled and sepsis screen was sent. Results: On analyzing the results of the sepsis screen of all the enrolled patients it was found that, out of all sepsis positive cases, 28% had a gram positive infection while 72% had a gram negative infection. In all patients having Gram positive sepsis, 41% had an Enterococcus infection, while in those having Gram negative sepsis 42% had Klebsiella infection. It was observed that >50% Gram positive organisms were sensitive to Piperacillin + Tazobactum, Imipenem, Amikacin and Vancomycin. While >50% Gram negative organisms were sensitive to Piperacillin + Tazobactum and Imipenem. Conclusion: It can thus be concluded from the data that an empirical antibiotic therapy of Piperacillin + Tazobactum and Amikacin would be most efficacious in our set up as first line antibiotics rather than the combination of Cefotaxime and Amikacin which were being used up till now