SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES

The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthesized by treating 2-chloro benzothiazole with various cyclic amines. Purity of all the compounds has been checked on thin layer chromatographic plate technique. The structures of these newly synthesized compounds were characterized by elemental analysis and spectral data like IR, 1HNMR, 13CNMR and mass spectroscopy. All the synthesized compounds have been screened for their anti-microbial activity (MIC) in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal stains. The compounds exhibit significant antibacterial activity, when compared with that of standard drug Streptomycin. Also show moderate degree of antifungal activity when compared with a standard drug Amphotericin-B.