SYNTHESIS, CHARACTERIZATION AND ANTIMALARIAL–ANTIMICROBIAL STUDIES OF SOME NOVEL DERIVATIVES OF CHLOROQUINOLINE BASED PYRAZOLES

The prime aim of the present investigation was to synthesize a series of novel derivatives of pyrazole based quinolines by the reaction of substituted chalcones and characterized them by their physical and spectral data. All the compounds were confirmed by TLC and melting point. The structures of the synthesized compounds have been established on the basis of IR, 1 H NMR, EIMS spectral analysis and elemental analysis. The synthesized target compounds were screened for their anti-malarial activity using Vero cell line (C1008; Monkey kidney fibroblast) against Plasmodium falciparum (3D7 strain) with the standard and SI was measured by using IC50 and CC50 of tested compounds. Additionally, the synthesized compounds were evaluated for their in vitro antimicrobial activity against two each gram positive, gram negative and antifungal strains.