Association between type 2 diabetes mellitus and hypovitaminosis D

Introduction: Vitamin D is an important component in regulating the biological functions of the body in various ways. Many studies repeatedly explained the role of vitamin D in the pathogenesis and treatment of various diseases. Recent studies proved a correlation between vitamin D deficiency and prevalence of Type 2 Diabetes and its complications. Objective: to find out the possible correlation between Vitamin D and T2DM. Mainly in this study we have tried to correlate serum 25(OH) D levels with HbA1c levels. Materials and Method: The present study was carried out in the Department of Biochemistry on 120 subjects patient in the age group of 35-70 years, attended OP in Hind Institute of Medical Sciences. Among them 60 healthy subjects enrolled as control group remaining 60 T2DM patients were served as case group. Serum 25hydroxyvitamin D levels were estimated by chemiluminescence immunoassay (CLIA), glycosylated hemoglobin (HbA1c) was measured by IFCC method by using ALERA AFINION AS 100. Results: The concentration of serum 25-OH vitamin D levels were significantly (p<0.0001) lower in cases (22.92±6.66) as compared to the controls (35.96± 8.46). There was negative correlation found between 25-OH vitamin D levels and glycosylated hemoglobin (HbA1c) in cases of type 2 DM. Conclusions: Prevalence of hypovitaminosis D was appeared to be more common T2DM patients in compare to non diabetic healthy population. There is a negative correlation exists between serum 25 hydroxy vitamin D and HbA1C (glycemic Control).