A study of association of sex hormone milieu with lipid profile for assessment of cardiovascular risk in adult women

Introduction: Women continue to have a high cardiovascular mortality than men in the past 20 years which is underestimated. Cardiovascular disease is clearly polyfactorial, and data on endogenous hormones may improve our prediction of risk. The endocrine environment in women is complex and changes with chronology. So this study becomes a need in women of middle age with objectives- 1. To analyse the level and association of serum Estradiol, Testosterone, SHBG, DHEA with lipid profile. 2. To assess the cardiovascular risk in adult women with respect to their androgenic status. Materials and Method: A cross-sectional study from 120 volunteered adult women of age between 20-40years selected and blood collected for biochemical assay of serum Estradiol, Testosterone, Steroid Hormone Binding Globulin, Dehydroepiandrosterone and lipid profile by standard methods. All quantitative data obtained were analysed with a set statistical significance at p<0.05. Results: In our study mean age of adult women was 29.05 ± 5.8 years. The mean of sex hormone profile were in normal range. Testosterone levels even in normal range showed a positive association with LDL-C (r=0.392, p<0.05), Atherogenic Index of Plasma (r=452, p<0.05) and negative association with HDL-C(r=-0.114, p=0.21). Conclusion: The study shows in adult women as the age advances the androgen levels influences dyslipidemia and cardiovascular risk.