Analysis of effect of trabeculectomy in adult primary open angle glaucoma patients using spectral domain optical coherence tomography in Indian population

Purpose: To evaluate the change in retinal nerve fiber layer thickness (RNFL) using Optical Coherence Tomography after trabeculectomy in adult patients with primary open angle glaucoma (POAG). Methods: A total of 40 eyes (30 patients) with POAG, uncontrolled on medical management were enrolled. Average and quadrant wise RNFL thickness were measured pre and post operatively at 1 week, 1 and 3 months. Data was analysed using SPSS software. Results: Intraocular pressure (IOP) reduced from 28.55+ 8.47 mm Hg, 14.8+ 5.97 mm Hg at 1 week, 14.25 + 4.47 mm Hg at 1 month, 14.9 +4.8 mm Hg at 3 months (p<0.0001)). There was no statistically significant change in RNFL level noted at 1 or 3 months (p=0.1847). Visual function (MD and PSD) also remained unchanged. RNFL thickness had significant negative correlation with age, IOP and pattern standard deviation. We divided the patients in two groups < 50 years and >50 years and analyzed the data but no statistically significant changes were found. Conclusion: In this study, post glaucoma filtration surgery, there was significant lowering of IOP but no difference in RNFL thickness, visual field parameters in adult POAG patients.