Impact of Phytohormones Auxin and Cytokinin on Mammalian Cells

Phytohormones are chemical signals released in minimum concentrations by plant cells to perform various important physiological and biological functions. Auxins and cytokinins are the two major classes of phytohormones. Current study deals with the effect of these phytohormones on mammalian cells. Our results suggested that both IAA (auxin) and kinetin (cytokinin) enhances the cell density of HEK293 and NIH3T3 mammalian cell lines after treatment without compromising cell viability. We also showed that both hormones augmented cell cycle process in both cell lines by increasing the expression of cyclins and decreasing the expression of cyclin-dependent kinase inhibitor p21. Our results provide an insight into the impact of phytohormones on mammalian cells.