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SYNTHESIS AND COMPUTATIONAL CALCULATIONS OF NOVEL CHIRAL BIS-1,2,3-TRIAZOLE DERIVATIVES

Journal: MATTER: International Journal of Science and Technology (Vol.3, No. 2)

Publication Date:

Authors : ; ;

Page : 165-176

Keywords : Enzymatic resolution; 1; 2; 3-Triazoles; Benzofuran; Benzothiophene; One-pot reaction;

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Abstract

The one-pot synthesis of novel bis-1,2,3-triazole derivatives from homopropargyl alcohol backbones is described. The key intermediates chiral 2-benzothiophenyl (-)-1 and 2-benzofuranyl (-)-2 substituted homopropargyl alcohols are synthesized from their corresponding carboxyaldehyde derivatives by O-propargylation and enzymatic resolution. Enantiomerically enriched homopropargyl alcohol derivatives are reacted with diiodo benzene and sodium azide via one-pot synthesis method and novel chiral bis-benzofuranyltriazole (-)-3 and bis-benzothiophenyltriazole (-)-4 are constructed without isolation of potentially toxic and unstable organic azide intermediates.

Last modified: 2018-04-26 19:23:03